Mg OptimaTM Relax contains evidence based ingredients that may support the natural metabolic pathways for gamma-aminobutyric acid (GABA) production and activity, indicated to promote relaxation during times of stress. Albion ® Magnesium bisglycinate is scientifically designed to provide a highly bioavailable form of magnesium. Magnesium may act as a GABA receptor agonist and also has a binding site on the glutamate receptors helping to regulate the activity of this main excitatory neurotransmitter. Glycine functions as an inhibitory neurotransmitter in the nervous system while glutamine is a precursor to GABA production. Theanine is an amino acid from Green Tea that may promote relaxation via binding to glutamate receptors. Pyridoxal (vitamin B6) is a cofactor for the enzyme Glutamate decarboxylase that synthesises GABA from glutamate. Zinc also has a binding site on the glutamate receptor and may act as a modulator for both excitatory and inhibitory neurotransmission.

STANDARD INDICATIONS

• Help reduce effects of mild anxiety and nervous tension.
• Non-vitamin active ingredients in this product help relieve nervous tension, stress and mild anxiety. For the symptomatic relief of stress disorders.
• May assist in the management of stress disorders.
• Beneficial during times of stress.
• Non-vitamin active ingredients in this product may be beneficial during times of stress.
• Non-vitamin active ingredients may improve stress adaptation.
• Herbal blend which helps relieve stress of study or work.
• May help reduce the frequency of migraines.
• Helps relieve nervous tension, stress and mild anxiety.
• For the symptomatic relief of anxiety.
• May assist in the management of anxiety.
• Relief of muscular aches and pains.

SPECIFIC INDICATIONS

• Magnesium is primarily found within the cell where it acts as a counter ion for the energy-rich ATP and nuclear acids.
• Magnesium is a cofactor in more than 300 enzymatic reactions. It critically stabilises enzymes, including many ATP-generating reactions. ATP is required universally for glucose utilisation, synthesis of fat, proteins, nucleic acid and coenzymes, muscles contraction, methyl group transfer and many other processes.
• ATP metabolism, muscle contraction and relaxation, normal neurological function and release of neurotransmitters are all magnesium dependent.
• Magnesium contributes to the regulation of vascular tone, heart rhythm, proper blood coagulation and bone formation.
• Magnesium may modulate blood sugar regulation and cell proliferation in healthy individuals and is important for cell adhesion and transmembrane transport including transport of potassium and calcium ions.
• Magnesium maintains the conformation of nucleic acids and is essential for the structural function of proteins and mitochondria.
• Early signs of magnesium deficiency may include loss of appetite, nausea, vomiting, fatigue and weakness and as magnesium deficiency worsens it may be associated with numbness, tingling, muscle contractions and cramps.
• Hypomagnesaemia is common in hospitalised patients.
• Glycine is the major inhibitory neurotransmitter in caudal regions of the adult mammalian central nervous system with high densities of glycinergic synapses being found in spinal cord and brain stem.
• Glycine has important neurotransmitter functions at inhibitory and excitatory synapses in the central nervous system.
• L-theanine is one of the primary amino acids found in green tea and can pass over the blood-brain brain barrier increasing levels of concentration in the brain.
• L-theanine can affect the secretion and function of neurotransmitter in the central nervous system.
• L-theanine has an affinity to bind to the glutamate receptor subtypes. L-theanine blocks the binding of L-glutameric acid to the glutamate receptors in the brain, resulting in an anti-stress effect through inhibition of cortical neutron excitation.
• L-theanine through competitive action against excitation of glutamate receptor subtypes, neurochemical studies suggest that L-theanine affects emotions by interacting with serotonin, dopamine and GABA neurotransmitter levels.
• Dose-dependant administration of L-theanine may affect metabolism and/or the release of specific neurotransmitters in the brain.
• L-theanine induces alpha wave brain activity, which relates to a perceived state of relaxation.
• L-theanine may help to reduce anxiety levels and attenuate increased blood pressure in high-stress response adults.
• L-theanine has a positive effect on mood and cognitive performance, resulting in increased energy, clarity of thought, efficiency, increased alertness and increased perceived work performance.
• L-theanine may result in a reduction of heart rate and salivary immunoglobulin A responses during times of acute stress.
• Zinc may function as an inhibitory neuromodulator of glutamate release in the brain.
• Approximately 10% of total zinc in the brain exists in synaptic vesicles of glutamatergic neutrons.
• Zinc is likely to modulate neurotransmission mediated via excitatory and inhibitory amino acid receptors at specific synapses.
• Pyridoxal (B6) is involved in the regeneration of tetrahydrofolate into the active methyl- bearing form and in glutathione biosynthesis from homocysteine.
• L-Glutamine is an amino acid precursor to the neurotransmitter GABA, the major inhibitory neurotransmitter in the central nervous system.